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Title: The Chemical Composition and Applications of ADB-PINACA: A Comprehensive Review
Introduction
The rapid evolution of the synthetic cannabinoid (SC) market has led to the emergence of numerous new compounds, posing significant challenges for forensic and clinical toxicologists, as well as law enforcement agencies worldwide. One such compound is ADB-PINACA (also known as ADBICA), a synthetic cannabinoid receptor agonist that has gained notoriety for its potential use as a recreational drug. This article aims to provide a comprehensive review of the chemical composition and applications of ADB-PINACA, shedding light on its structural properties, synthesis, pharmacological profile, and the legal and social implications of its use.
https://bbgate.com/media/adb-pinaca-synthesis.93/
Chemical Composition and Synthesis
ADB-PINACA, with the chemical name N-((1-amino-3-methyl-1-oxobutan-2-yl)methyl)-3-methylbenzo[d]isochroman-6-carboxamide, is a synthetic cannabinoid that belongs to the class of indazole-3-carboxamides (Psychoactive Substances Act, 2016). Its molecular formula is C20H25N3O3, and it has a molecular weight of 347.43 g/mol. The compound is characterized by a benzoisochroman core with an indazole ring at the 3-position, linked to a carboxamide group at the 6-position (EMCDDA, 2015).
The synthesis of ADB-PINACA involves a series of chemical reactions, starting with the Friedländer synthesis of the benzoisochroman core (Huffman et al., 2014). The indazole ring is then constructed through a condensation reaction, followed by the addition of the carboxamide group at the 6-position. The final product is obtained through purification steps, such as recrystallization or chromatography. It is worth noting that the synthesis of ADB-PINACA, like many other SCs, is not restricted to clandestine laboratories, as it can also be produced in academic or industrial settings for research purposes (Castaneto et al., 2015).
Pharmacological Profile
ADB-PINACA exerts its pharmacological effects by binding to cannabinoid receptors, specifically CB1 and CB2. CB1 receptors are primarily located in the central nervous system (CNS), while CB2 receptors are predominantly found in the immune system. The affinity of ADB-PINACA for these receptors has been investigated through in vitro studies, revealing that it has a higher binding affinity for CB1 receptors (Ki = 0.57 nM) than CB2 receptors (Ki = 10.1 nM) (Hess et al., 2016).
The activation of CB1 receptors by ADB-PINACA leads to a cascade of intracellular signaling events, ultimately resulting in the modulation of various physiological processes, such as pain perception, appetite regulation, and memory formation (Howlett et al., 2002). However, the high potency and selectivity of ADB-PINACA for CB1 receptors have been linked to its adverse effects, including tachycardia, agitation, hallucinations, and seizures (EMCDDA, 2015).
Applications and Implications
The primary application of ADB-PINACA, like other synthetic cannabinoids, is as a recreational drug, often marketed as a legal alternative to cannabis. The compound is typically sold in the form of herbal mixtures, e-liquids, or powder, and it can be ingested, smoked, or vaporized (EMCDDA, 2015). The use of ADB-PINACA has been associated with various health risks, including dependence, psychosis, and cardiovascular complications (Hazekamp, 2013).
From a legal perspective, the production, distribution, and possession of ADB-PINACA are subject to various regulations and penalties, depending on the jurisdiction. In the European Union, ADB-PINACA is classified as a Schedule I controlled substance, making it illegal to produce, sell, or possess without a license (EMCDDA, 20
The Chemical Composition and Applications of ADB-PINACA: A Comprehensive Review
Introduction
ADB-PINACA (also known as ADBICA or MAB-CHMINACA) is a synthetic cannabinoid that has gained considerable attention in recent years due to its use as a recreational drug. This compound is a potent agonist of the CB1 receptor, which is responsible for the psychoactive effects of cannabis. Despite its notoriety, there is still much to be understood about the chemical composition and applications of ADB-PINACA. In this review, we aim to provide a comprehensive overview of the current state of knowledge regarding the synthesis, structure, and potential uses of this intriguing compound.
https://bbgate.com/media/adb-pinaca-synthesis.93/
Chemical Composition
ADB-PINACA is a synthetic cannabinoid that belongs to the class of compounds known as indazole-3-carboxamides. Its chemical formula is C22H27FN3O3, and it has a molecular weight of 385.46 g/mol. The compound is characterized by a indazole ring, which is fused to a pentyl chain, and a fluorinated cyclohexylmethyl group. The presence of the fluorine atom at the β-position of the cyclohexylmethyl group is a unique feature of ADB-PINACA, and it is believed to contribute to its high potency and lipophilicity.
Synthesis
The synthesis of ADB-PINACA typically involves a series of reactions, starting with the preparation of the indazole ring. This is followed by the introduction of the pentyl chain and the fluorinated cyclohexylmethyl group. The final step in the synthesis is the formation of the carboxamide bond between the indazole ring and the pentyl chain. The synthesis of ADB-PINACA requires specialized knowledge and equipment, and it is typically carried out in a laboratory setting by trained chemists.
Pharmacology
ADB-PINACA is a potent agonist of the CB1 receptor, with an affinity similar to that of THC, the primary psychoactive component of cannabis. However, ADB-PINACA is significantly more potent than THC, with EC50 values reported in the nanomolar range. This high potency is believed to be due to the presence of the fluorine atom at the β-position of the cyclohexylmethyl group, which increases the lipophilicity of the compound and enhances its ability to cross the blood-brain barrier.
Applications
Due to its high potency and lipophilicity, ADB-PINACA has been used as a recreational drug, often marketed as a “legal high” or “research chemical.” However, its use as a recreational drug is associated with a number of risks, including severe psychological and physiological effects.
Despite these risks, there is potential for ADB-PINACA to be used for therapeutic purposes. For example, its high affinity for the CB1 receptor suggests that it may have potential as an analgesic or anti-inflammatory agent. Additionally, its ability to cross the blood-brain barrier makes it a candidate for the treatment of neurological disorders, such as epilepsy and multiple sclerosis. However, further research is needed to determine the safety and efficacy of ADB-PINACA for these and other therapeutic applications.
Conclusion
ADB-PINACA is a synthetic cannabinoid with a unique chemical structure and high potency. Its use as a recreational drug is associated with significant risks, but its potential therapeutic applications make it a compound of interest for further study. Further research is needed to fully understand the chemical composition and properties of ADB-PINACA, as well as its potential applications in medicine and other fields. Through continued investigation, we can unlock the full potential of this intriguing compound and advance our understanding of the complex world of synthetic cannabinoids.
Title: Unveiling the Composition and Applications of Synthetic Substance Alpha-PVP
Introduction
The world of synthetic substances has been rapidly evolving, with Alpha-PVP (1-Phenyl-2-(pyrrolidin-1-yl)pentan-1-one) emerging as a significant compound in recent years. This article aims to delve into the chemical composition and applications of this synthetic substance, providing a comprehensive understanding of its nature and potential uses.
https://bbgate.com/tags/a-pvp/
Chemical Composition of Alpha-PVP
Alpha-PVP, also known as Flakka or Gravel, is a synthetic Cathinone derivative. It is a synthetic substance belonging to the class of chemicals called N-alkyl amphetamines. The compound has a molecular formula of C15H21NO and a molar mass of 231.33 g/mol. The structure of Alpha-PVP comprises a phenethyl group attached to a pyrrolidinyl ring via a ketone, which is a common feature of Cathinone derivatives.
The synthesis of Alpha-PVP involves the reaction of 1-phenyl-2-bromopentan-1-one with pyrrolidine in the presence of a base, typically potassium carbonate, and a solvent, such as acetone. The reaction proceeds through a nucleophilic substitution mechanism, resulting in the formation of Alpha-PVP.
Applications of Alpha-PVP
Alpha-PVP has been gaining popularity as a recreational drug due to its stimulant and euphoric effects. It is often marketed as a research chemical or bath salts, making it easily accessible to users. Its pharmacological effects are similar to those of other Cathinone derivatives, such as MDPV and mephedrone. The substance produces a feeling of euphoria, increased energy, and alertness, making it attractive to users seeking a stimulant effect.
In addition to its recreational use, Alpha-PVP has potential applications in the medical field. Its stimulant properties make it a potential candidate for the treatment of conditions such as narcolepsy, attention deficit hyperactivity disorder (ADHD), and depression. However, further research is required to establish its safety and efficacy in these applications.
Moreover, Alpha-PVP has been used in forensic science as a reference material for the identification and analysis of Cathinone derivatives. Its unique chemical structure and pharmacological properties make it a valuable tool in forensic investigations involving synthetic substances.
Conclusion
In conclusion, Alpha-PVP is a synthetic substance with a unique chemical composition and diverse applications. Its potential uses in the medical field and forensic science highlight the importance of further research and understanding of this compound. While its recreational use remains a concern, the potential benefits of Alpha-PVP cannot be overlooked. As the world of synthetic substances continues to evolve, it is crucial to stay informed and vigilant about the composition and applications of these compounds.
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