{"id":9986,"date":"2025-03-26T21:37:33","date_gmt":"2025-03-27T04:37:33","guid":{"rendered":"https:\/\/dhs.lacounty.gov\/harbor-ucla-medical-center\/?page_id=9986"},"modified":"2025-03-28T11:02:01","modified_gmt":"2025-03-28T18:02:01","slug":"publications","status":"publish","type":"page","link":"https:\/\/dhs.lacounty.gov\/harbor-ucla-medical-center\/work-or-partner-with-us\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

[vc_row][vc_column][vc_single_image image=”10003″ img_size=”768×330″ css=””][vc_tta_accordion active_section=”10″ collapsible_all=”true”][vc_tta_section title=”A prehospital protocol for transfusion of low-titer O-positive whole blood in patients with hemorrhagic shock in Los Angeles County: Modeling the risk of hemolytic disease of the fetus and newborn” tab_id=”1741717285072-58439cf8-a35e”][vc_column_text css=””]<\/p>\n

The Los Angeles Development and Rapid Operationalization of Prehospital Blood (LA-DROP) pilot will protocolize prehospital administration of low titer O-positive whole blood (LTO\u2009+\u2009WB) to patients with hemorrhagic shock in Los Angeles County (LAC). We sought to quantify the risk of death from hemolytic disease of the fetus and newborn (HDFN) associated with RhD-negative alloimmunization in females of childbearing potential (FCPs) as a result of LA-DROP.<\/p>\n

[\/vc_column_text][vc_btn title=”Read More” align=”center” css=”” button_block=”true” link=”url:https%3A%2F%2Fdoi.org%2F10.1111%2Ftrf.18184|title:Read%20More|target:_blank”][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row][vc_row][vc_column][vc_text_separator title=”Related Publications” border_width=”5″ css=””][vc_tta_accordion active_section=”10″ collapsible_all=”true”][vc_tta_section title=”Every minute matters: Improving outcomes for penetrating trauma through prehospital advanced resuscitative care” tab_id=”1741717966649-f1ec1e5c-72f0″][vc_column_text css=””]Prehospital resuscitation with blood products is gaining popularity for patients with traumatic hemorrhage. The MEDEVAC trial demonstrated a survival benefit exclusively among patients who received blood or plasma within 15 minutes of air medical evacuation. In fast-paced urban EMS systems with a high incidence of penetrating trauma, mortality data based on the timing to first blood administration is scarce. We hypothesize a survival benefit in patients with severe hemorrhage when blood is administered within the first 15 minutes of EMS patient contact.[\/vc_column_text][vc_btn title=”Read More” align=”center” css=”” button_block=”true” link=”url:https%3A%2F%2Fjournals.lww.com%2Fjtrauma%2Fabstract%2F2024%2F11000%2Fevery_minute_matters__improving_outcomes_for.8.aspx|title:Read%20More|target:_blank”][\/vc_tta_section][vc_tta_section title=”Another piece of the hemolytic disease of the fetus and newborn puzzle after RhD-positive transfusion in trauma resuscitation: the proportion of pregnant women who produce high titer anti-D” tab_id=”1741717966656-805eaadc-b0cf”][vc_column_text css=””]After the transfusion of RhD-positive red blood cell (RBC)-containing products to an RhD-negative woman of childbearing potential (WCP) during trauma resuscitation, there are several events that must occur for that WCP to have a future pregnancy affected by hemolytic disease of the fetus and newborn (HDFN). This study identified and quantitated the frequency of a novel event in the sequence from RhD-positive transfusion during trauma resuscitation to an HDFN outcome, that is, the development of a high titer anti-D among women who were D-alloimmunized.[\/vc_column_text][vc_btn title=”Read More” align=”center” css=”” button_block=”true” link=”url:https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC10773421%2F|title:Read%20More|target:_blank”][\/vc_tta_section][vc_tta_section title=”Use of Cold-Stored Whole Blood is Associated With Improved Mortality in Hemostatic Resuscitation of Major Bleeding” tab_id=”1741727310619-a3dca0be-acb1″][vc_column_text css=””]Blood component therapy (BCT) is the current standard for resuscitating trauma patients, with WB emerging as the blood product of choice. We hypothesized that the use of WB versus BCT alone would result in decreased mortality.[\/vc_column_text][vc_btn title=”Read More” align=”center” css=”” button_block=”true” link=”url:https%3A%2F%2Fjournals.lww.com%2Fannalsofsurgery%2Fabstract%2F2022%2F10000%2Fuse_of_cold_stored_whole_blood_is_associated_with.2.aspx|title:Read%20More|target:_blank”][\/vc_tta_section][vc_tta_section title=”Prehospital Whole Blood Reduces Early Mortality in Patients with Hemorrhagic Shock” tab_id=”1741727421994-6471284a-9d01″][vc_column_text css=””]Low titer O+ whole blood (LTOWB) is being increasingly used for resuscitation of hemorrhagic shock in military and civilian settings. The objective of this study was to identify the impact of prehospital LTOWB on survival for patients in shock receiving prehospital LTOWB transfusion.[\/vc_column_text][vc_btn title=”Read More” align=”center” css=”” button_block=”true” link=”url:https%3A%2F%2Fonlinelibrary.wiley.com%2Fdoi%2F10.1111%2Ftrf.16528|title:Read%20More|target:_blank”][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row][vc_row][vc_column][vc_text_separator title=”POSITION STATEMENTS” border_width=”5″ css=””][vc_column_text css=””]International Association of Emergency Medical Services Chiefs (IAEMSC)<\/a><\/p>\n

Prehospital Hemorrhage Control and Treatment by Clinicians: A Joint Position Statement by ACEP, NAEMP, ACSCOT<\/a>[\/vc_column_text][vc_separator border_width=”5″ css=””][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_single_image image=”10003″ img_size=”768×330″ css=””][vc_tta_accordion active_section=”10″ collapsible_all=”true”][vc_tta_section title=”A prehospital protocol for transfusion of low-titer O-positive whole blood in patients with hemorrhagic shock in Los Angeles County: Modeling the risk of hemolytic disease of the fetus and newborn” tab_id=”1741717285072-58439cf8-a35e”][vc_column_text css=””] The Los Angeles Development and Rapid Operationalization of Prehospital Blood (LA-DROP) pilot will protocolize prehospital administration of […]<\/p>\n","protected":false},"author":18,"featured_media":0,"parent":9000,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/template-subsite-basic-page.php","meta":{"_oasis_is_in_workflow":0,"_oasis_original":0,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[],"tags":[],"class_list":["post-9986","page","type-page","status-publish","hentry"],"yoast_head":"\nPublications - 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