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Monoclonal Antibody Therapy for COVID-19

Jan 2022 (UPDATE) – Due to the prevalence of the Omicron variant (>80% of current infections), REGEN-COV (casirivimab/imdevimab) and bamlanivimab/etesevimab are no longer recommended for treatment or post-exposure prophylaxis of COVID-19 in Los Angeles County because they are not expected to be effective against the Omicron variant. Sotrovimab remains a recommended treatment but, is in limited supply.

Acute care hospitals that have received allocations of sotrovimab in Los Angeles County can be found here (because supplies are limited, being listed does not confirm current availability).

Evusheld is a long-acting antibody authorized for pre-exposure prophylaxis (prevention) in people with moderate to severe immune compromise due to a medical condition or immunosuppressive medication who may not mount an adequate immune response to COVID-19 vaccine.

Additional therapeutics include Paxlovid and molnupiravir which are oral antiviral medications authorized for the treatment of COVID-19 in people that are at high risk for progression to severe disease. 

These therapeutics are also in limited supply.  More information about COVID-19 therapeutics and access to them in Los Angeles County can be found here:
http://publichealth.lacounty.gov/acd/ncorona2019/therapeutics/

A federal link to therapeutics distribution can also be found here:
https://covid-19-therapeutics-locator-dhhs.hub.arcgis.com/

Acute care hospitals that have received allocations of sotrovimab in Los Angeles County can be found here (because supplies are limited, being listed does not confirm current availability).

 

Monoclonal antibodies are laboratory-made proteins that mimic the immune system’s ability to fight off harmful pathogens such as viruses. REGEN-COV (casirivimab/imdevimab), bamlanivimab/etesevimab, and sotrovimab are monoclonal antibody therapies specifically directed against the spike protein of SARS-CoV-2, designed to block the virus’ attachment and entry into human cells.

Monoclonal antibody therapy may be effective in treating patients with mild or moderate COVID-19, preventing progression and severity of symptoms.  The FDA issued Emergency Use Authorization (EUA) for this treatment for COVID-19 in patients with mild to moderate symptoms and that are high risk for progression to severe COVID-19 and/or hospitalization.  The FDA has also authorized the use of REGEN-COV and bamlanivimab/etesevimab for post-exposure prophylaxis (prevention) in people who have been exposed to the SARS-CoV-2 virus and are at high risk for progression to severe COVID-19. Prophylaxis with REGEN-COV is not a substitute for vaccination against COVID-19. Monoclonal antibodies are not authorized for use in hospitalized patients that are 2 years or older.  Bamlanivimab/etesevimab is authorized for patients of all ages that meet emergency use authorization criteria, including neonates.



Patient Information

Are you eligible for Monoclonal Antibody Treatment for COVID-19?

Monoclonal Antibody Eligibility Screening Tool

Healthcare Provider Information

Healthcare providers may request information about receiving allocations of monoclonal antibodies by emailing this address:  laemsadutyofficer@dhs.lacounty.gov.  However, the EMS Agency is dependent on receiving federal shipments of these medications, and quantities have been extremely limited at times.

 

Monoclonal Antibody Access

Monoclonal Antibody Treatment is accessible in many locations throughout Los Angeles County for eligible patients:

  1. The state is sponsoring Monoclonal Antibody access sites:

+Hawaiian Gardens MAB & Testing Center Address
21530 Pioneer Blvd
Hawaiian Gardens, CA  90716

Hawaiian Gardens MAB Site Hours:
Monday – Saturday
8am to 6pm

Patient & Physician Line:
(209) 494-6318

COVID-19 Walk-up Testing Kiosk
Operation Hours:
Wednesday – Sunday
8:30am – 3:30pm
Location Address:
21530 Pioneer Blvd
Hawaiian Gardens, CA  90716

+ContinuEM Urgent Care Address:
6430 South Street
Lakewood, CA 90713

ContinuEM MAB site hours:
Mon-Fri 9am to 10:30pm
Sat/Sun 10am to 5pm

      • Same day patients accepted
      • Patient self-referral and physician referral line: 562-731-3990

2. Your primary care provider may be able to refer you to receive an infusion through your health care plan.

3. Many Emergency Departments and Infusion Clinics offer monoclonal antibody.

Locations identified as offering monoclonal antibody infusions are listed here:

https://covid.infusioncenter.org/

(contact the location for access information)

4. There are local facilities offering monoclonal antibody treatment. The Department of Health and Human Services maintains a national database (call site of interest for details).

https://protect-public.hhs.gov/pages/therapeutics-distribution#distribution-locations

5. The Department of Health and Human Services, CombatCovid program can be contacted for information on monoclonal antibody resources and locations.

Phone Number: (877)332-6585

https://combatcovid.hhs.gov/i-have-covid-19-now/monoclonal-antibodies-high-risk-covid-19-positive-patients