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Monoclonal Antibody Therapy for COVID-19

Monoclonal antibodies are laboratory-made proteins that mimic the immune system’s ability to fight off harmful pathogens such as viruses. Bebtelovimab is a monoclonal antibody therapy specifically directed against SARS-CoV-2, designed to block the virus’ attachment and entry into human cells. Currently, bebtelovimab is the only monoclonal antibody authorized for treatment of COVID-19.  The use of sotrovimab, REGEN-COV, and bamlanivimab/etesevimab is no longer authorized for treatment or post-exposure prophylaxis (prevention) of COVID-19 in the U.S. due to lack of effectiveness against the Omicron variants.

Monoclonal antibody therapy may be effective in treating patients with mild or moderate COVID-19, preventing progression and severity of symptoms.  The FDA has issued Emergency Use Authorizations (EUAs) for treatment for COVID-19 with monoclonal antibodies in patients with mild to moderate symptoms and that are high risk for progression to severe COVID-19 and/or hospitalization.



Patient Information

Are you eligible for Monoclonal Antibody Treatment for COVID-19?

Monoclonal Antibody Eligibility Screening Tool

Healthcare Provider Information

Bebtelovimab is available for direct commercial purchase by authorized medical entities through the distributor, AmerisourceBergen.  Healthcare entities interested in acquiring bebtelovimab can contact the distributor at c19therapies@amerisourcebergen.com.

The Los Angeles County EMS Agency will no longer allocate bebtelovimab once the federally purchased supply is depleted (August 2022).

Monoclonal Antibody Access

Monoclonal Antibody Treatment is accessible in many locations throughout Los Angeles County for eligible patients:

  1. A federal link to COVID-19 therapeutics distribution can be found here:
    https://covid-19-therapeutics-locator-dhhs.hub.arcgis.com/

Locations that have received bebtelovimab and reported availability are listed.

 

  1. The state is sponsoring Monoclonal Antibody access sites:

+ContinuEM Urgent Care Address:
6430 South Street
Lakewood, CA 90713

ContinuEM MAB site hours:
Mon-Fri 9am to 10:30pm
Sat/Sun 10am to 5pm

  • Same day patients accepted
  • Patient self-referral and physician referral line: 562-731-3990

Other Therapeutics

The Los Angeles County Department of Public Health is managing the distribution of other COVID-19 therapeutics.

Evusheld is a long-acting antibody authorized for pre-exposure prophylaxis (prevention) in people with moderate to severe immune compromise due to a medical condition or immunosuppressive medication who may not mount an adequate immune response to COVID-19 vaccine.

Additional therapeutics include Paxlovid and molnupiravir which are oral antiviral medications authorized for the treatment of COVID-19 in people that are at high risk for progression to severe disease.

More information about COVID-19 therapeutics and access to them in Los Angeles County can be found here:  http://publichealth.lacounty.gov/acd/ncorona2019/therapeutics/